to describe it as torturous.” So why do some people’s legs do this?
According to the NIH, “in most cases, the cause of RLS is unknown,” though “it may have a genetic component.” Nevertheless, experts do have some inkling of the cause, as the NIH reports on their website: Considerable evidence suggests that RLS is related to a dysfunction in the brain’s basal ganglia circuits that use the neurotransmitter dopamine, which is needed to produce smooth, purposeful muscle activity and movement.
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Disruption of these pathways frequently results in involuntary movements.
Capitalizing on this finding, pharmaceutical companies developed drugs affecting the dopamine system, which have grown into the primary treatment for RLS.
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